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Cholera is an acute epidemic infectious disease. It can be characterized by watery diarrhoea, severe dehydration and extreme loss of fluids and electrolytes. Cholera is caused due to bacterium Vibrio cholera. According to an article published in NCBI, researchers has estimated that 1.3 million to 4.0 million cases of cholera are reported each year in endemic countries.
Current treatment for cholera includes administration of oral rehydration solution (ORS) and antibiotics. The main aim of current treatments is restoration of fluids, and reduction of fluid loss. Zinc is used for treatment of cholera in pediatric patients. World Health Organization has approved Dukoral, Shanchol, and Euvichol-Plus for the treatment of cholera.
Research Institutes and pharmaceutical companies have focussed on studying and developing new methods for the treatment of cholera. For instance; HL-OCV, which is being studied by the International Centre for Diarrhoeal Disease Research, Bangladesh in collaboration with MSD Wellcome Trust Hilleman Laboratories Pvt. Ltd., is currently in phase-1 clinical trials for the study safety and immunogenicity outcome of the HL-OCV compared to Shanchol vaccine.
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Currently, more than 50% of the pipeline candidates for cholera are in phase 2 and phase 3 stage. Majority of the studies have been sponsored by research institutes.
The report on ‘Cholera– Pipeline Review, 2019’ provides a comprehensive overview of the drugs that are in the R&D pipeline by indication or molecule for cholera. The report provides a thorough analysis of the distribution of the pipeline products by clinical trial stage, indication, company, therapy area and details such as clinical trial stage, sponsor, description on every product in the pipeline. Products in the preclinical and clinical stage along with dormant & discontinued pipeline candidates are included in the report. The report also covers additional insights such as epidemiology overview and current market scenario for cholera.
The report on ‘Cholera – Pipeline Review, 2019’, which is built by following a robust research methodology involving primary interviews and desk research, provides a complete overview of the R&D activity and pipeline products to assist companies in developing growth strategies and identifying emerging players.
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