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Choroidal neovascularization (CNV) is the formation of new blood vessels in the choroid layer of the eye. Choroidal neovascularization is a common cause of neovascular degenerative maculopathy. Choroidal neovascularization can be caused due to macular degeneration, myopia, ocular trauma, and others. Choroidal neovascularization creates a sudden deterioration of central vision, color disturbances, and metamorphopsia. Choroidal neovascularization is detected by using preferential hyperacuity perimetry. According to the article published in 2014, Pathologic myopia has been affecting up to 3% of the global population. Out of which, a substantial proportion of patients develop myopic CNV.
Current treatment for choroidal neovascularization includes anti-VEGF drugs, thermal laser treatment or photodynamic therapy (PDT). Some of the Food and Drug Administration (FDA) approved angiogenesis inhibitors include pegaptanib, ranibizumab, and bevacizumab. Choroidal neovascularization (CNV) can also be treated with photodynamic therapy coupled with a photosensitive drug such as verteporfin (Visudyne).
Research Institutes and pharmaceutical companies have focussed on studying and developing new methods for the treatment of choroidal neovascularization. For instance; E10030, which is being studied by the Ophthotech Corporation, is currently in phase-3 clinical trials for the study of the Safety and Efficacy study of Fovista (E10030) intravitreous administration in combination with Lucentis compared to Lucentis monotherapy.
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Currently, more than 50% of the pipeline candidates for choroidal neovascularization are in phase 1 and phase 2 stage. Majority of the studies have been sponsored by pharmaceutical companies.
The report on ‘Choroidal Neovascularization – Pipeline Review, 2019’ provides a comprehensive overview of the drugs that are in the R&D pipeline by indication or molecule for choroidal neovascularization. The report provides a thorough analysis of the distribution of the pipeline products by clinical trial stage, indication, company, therapy area and details such as clinical trial stage, sponsor, description on every product in the pipeline. Products in the preclinical and clinical stage along with dormant & discontinued pipeline candidates are included in the report. The report also covers additional insights such as epidemiology overview and current market scenario for choroidal neovascularization.
The report on ‘Choroidal Neovascularization – Pipeline Review, 2019’, which is built by following a robust research methodology involving primary interviews and desk research, provides a complete overview of the R&D activity and pipeline products to assist companies in developing growth strategies and identifying emerging players.
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